Mid-Dermal Filler for Moderate to Severe Facial Folds and
Perlane, approved by the FDA in May of this year, is a "mid-dermal" hyaluronic
acid filler product. As a sister product to Restylane, Perlane is designed for more
pronounced facial folds and wrinkles such as those on the sides of the mouth.
Perlane is injected into the deep dermis to superficial layer of the subcutis to add
volume to restore surface contour in facial wrinkles and folds. Perlane
corrections maintain volume augmentation for about six months before natural
product degradation begins to lessen the effects.
Q What is Perlane® used for?
A Perlane® is used to smooth moderate to severe facial folds and wrinkles such
as the lines from the nose to the corners of the mouth (nasolabial folds).
Perlane® generally lasts for about 6 months. It has been found to be a safe
dermal filler that restores volume and fullness to the skin.
Q How does Perlane® work?
A Perlane® is injected into the skin with an ultrafine needle. It plumps the skin to
smooth away wrinkles and folds. Perlane®’s water-loving nature attracts and
binds water molecules to help maintain volume.
Perlane® is composed of hyaluronic acid, a natural substance that already exists
in the body. The hyaluronic acid in Perlane® is a crystal clear gel that is
chemically cross-linked (the long chemical strands are tied together) to delay
breakdown by skin enzymes. Perlane® is non-animal-based and free from
animal protein. This quality prevents disease transmission.
Allergy pre-testing is not necessary.
Q How long does Perlane® last?
A Perlane® is proven to deliver long-lasting results. Studies have shown that
Perlane® effects generally last about six months as shown in the following
graphs. Perlane® gradually disappears.
Before Treatment After Treatment
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Perlane® has been used safely by dermatologists and plastic surgeons
since 2000 worldwide.
Q Who should not use Perlane® (Contraindications)?
A Perlane® should not be used by people with previous bad allergies
(particularly to certain microorganisms known as gram positive bacteria),
to drugs that have required in-hospital treatment, or in people with bleeding
disorders. Perlane® should not be injected anywhere except the skin or just
under the skin.
Q What are some warnings to consider?
A The use of Perlane® at sites with skin sores, pimples, rashes, hives, cysts,
or infections should be postponed until healing is complete.
Use of Perlane® in these instances could delay healing or make your skin
You may experience skin discoloration (bruising), swelling, redness,
tenderness, pain, itching, or small lumps in the area where you are injected. If
any of these events occur, the majority usually last less than seven days. If
any symptom lasts longer than two weeks, call the doctor who administered
the Perlane® injection.
Inflammatory papules (red or swollen small bumps) may rarely occur. You
may need antibiotics to treat them.
Q What are some risks that may be experienced?
A As with all procedures like this, the injection of Perlane® carries a
theoretical risk of infection and formation of scar tissue.
The safety and effectiveness of Perlane® have not been established in the
treatment of lips, in nursing mothers, and in patients under 18 or over 65
years of age. Perlane® use in nursing could harm you or the nursing child.
The use of Perlane® in African-American patients can result in
(darkening of skin color), which may take several weeks to correct.
If you have had herpes before, an injection can cause the herpes to come
The safety of Perlane® used with other skin therapies such as laser,
mechanical or chemical peeling, and hair removal has not been established.
The use of Perlane® in these skin therapies may not work or they may
damage your skin.
You should avoid exposing the area(s) treated with Perlane® to excessive
UV lamps, and extreme heat and cold until any redness or swelling has
Q What should patients do prior to treatment?
A Perlane® requires no pretesting, but you should take a few precautions
before being treated. Avoid using St. John’s Wort, high doses of Vitamin E
supplements, aspirin, and other non-steroidal anti-inflammatory medications,
such as ibuprofen prior to treatment, because these may increase bruising
or bleeding at the injection site. Also, if you have previously suffered from
sores, discuss this with your physician. He or she may consider prescribing
a medication to minimize recurrence.
Q Do the injections hurt?
A Perlane® is injected directly into the skin in tiny amounts by an ultrafine
needle. To help maximize your comfort, you should discuss the use of
numbing medicines with your doctor before treatment.
Q How much do Perlane® treatments cost?
A Perlane® is a customized procedure based on your specific needs, so the
cost will vary from patient to patient. In general, the cost of Perlane® is
comparable to the cost of similar procedures. Because Perlane® is long
lasting, it may prove to be very economical over the long term. Please ask
your doctor to give you an estimate of the cost.
What Areas of the Face Can Be Treated with Perlane®?
The hyaluronic acid in Perlane® can be used to improve the contour of facial
skin and to reduce wrinkles, folds, scars, and other facial skin depressions.
Common uses for Perlane® filler include:
• Wrinkle correction
• Diminishing worry lines, smile lines, crow’s feet, marionette lines at
corners of the mouth, and smoker’s lines
• Lip enhancement
• Reducing the severity of nasolabial folds
• Chin augmentation
• Filling cheek depressions
• Redefining lip border
• Softening acne scars
Other, less common, uses for Perlane® filler include:
• Filling hollows under the eyes
• Creating a temporary eyebrow lift
• Correcting facial depressions caused by fat loss
• Softening the appearance of jowls
Restylane® vs. Perlane® Filler
Perlane® is primarily the same product as Restylane®, but Perlane® filler
contains a larger concentration of hyaluronic acid. Because of this higher
concentration of hyaluronic acid, Perlane® is usually used for larger folds,
while Restylane® is better suited for smaller wrinkles or to maintain the
results of a previous Perlane® injection.
Because of the differing levels of hyaluronic acid, Restylane® is less
expensive than Perlane® filler.
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